December 2016. Volume 12. Number 4

Supplementation of women with n-3 LCPUFA during pregnancy did not reduce the incidence of allergic diseases in the six-year-old offspring

 
 
 
 
 
 
 
 
 
 
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AVC | Critically appraised articles

Best KP, Sullivan T, Palmer D, Gold M, Kennedy DJ, Martin J, et al. Prenatal fish oil supplementation and allergy: 6-year follow-up of a randomized controlled trial. Pediatrics. 2016;137. pii: e20154443.

Reviewer: García Vera C1.
1CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: César García Vera. Email: cgarciavera@gmail.com
Reception date: 15/11/2016
Acceptance date: 17/11/2016
Publication date: 23/11/2016

Abstract

Authors’ conclusions: no long-term benefit was demonstrated, in terms of allergic diseases reduction, for the children of mothers who received n-3 LCPUFA supplementation during pregnancy. In the assessment at six years of age, only a minor protective effect was found, against sensitization to one specific allergen (Dermatophagoides farinae)

Reviewers’ commentary: in line with the most recent systematic reviews, this trial, with some methodological problems (designed for the study of other variable result), demonstrated the lack of utility of n-3 LCPUFA supplements in pregnant women, to prevent allergic diseases in their children, at the age of six years.

How to cite this article

García Vera C. Suplementar con n-3 LCPUFA en embarazadas no disminuye la incidencia de enfermedades alérgicas en los hijos a los seis años de edad. Evid Pediatr. 2016;12:64.

AVC | Critically appraised articles

Best KP, Sullivan T, Palmer D, Gold M, Kennedy DJ, Martin J, et al. Prenatal fish oil supplementation and allergy: 6-year follow-up of a randomized controlled trial. Pediatrics. 2016;137. pii: e20154443.

Reviewer: García Vera C1.
1CS José Ramón Muñoz Fernández. Zaragoza. España.
Correspondence: César García Vera. Email: cgarciavera@gmail.com
Reception date: 15/11/2016
Acceptance date: 17/11/2016
Publication date: 23/11/2016

How to cite this article

García Vera C. Suplementar con n-3 LCPUFA en embarazadas no disminuye la incidencia de enfermedades alérgicas en los hijos a los seis años de edad. Evid Pediatr. 2016;12:64.

References

  1. Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P, et al. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA. 2010;304:1675-83.
  2. Gunaratne AW, Makrides M, Collins CT. Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood. Cochrane Database Syst Rev. 2015;(7):CD010085.
  3. Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, et al. Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial. BMJ. 2012;344:e184.
  4. Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, et al. Randomized controlled trial of fish oil supplementation in pregnancy on childhood allergies. Allergy. 2013;68:1370-6.
  5. Klemens CM, Berman DR, Mozurkewich EL. The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review. BJOG. 2011;118:916-25.
23/11/2016

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